Achalasia

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Achalasia.

Achalasia is the best understood and most readily treatable esophageal motility disorder. It serves as a prototype for disorders of the enteric nervous system with degeneration of the myenteric neurons that innervate the lower esophageal sphincter (LES) and esophageal body. Investigations into the pathogenesis have highlighted the importance of nitric oxide and the possible role of an autoimmun...

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Achalasia

Achalasia is a primary esophageal motor disorder characterized by lack of esophageal peristalsis and poor lower esophageal sphincter (LES) relaxation. Clinically, achalasia manifests as progressive dysphagia to solids and liquids and mild weight loss. Predisposition to esophageal cancer is not prevalent, but certain tumors may mimic achalasia. The diagnosis of achalasia is relatively easy to ma...

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Ayurvedic management of achalasia

Achalasia is an esophageal motor disorder characterized by sustained lower esophageal sphincter contraction and reduced esophageal peristalsis. This pathology eventually results in symptoms like dysphagia, regurgitation and occasional chest pain related to food intake. This is an uncommon disorder of unexplained etiology; however viral, autoimmune and neurodegenerative causes are often afflicte...

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Endoscopy in achalasia.

ENDOSCOPY has a very limited role in the diagnosis of achalasia but should always be undertaken when the radiologist suggests this diagnosis. The inspection of the oesophagus may be impaired by marked retention of food particles; we therefore lavage the organ routinely before starting endoscopy. Oesophagoscopy is principally used to rule out a stenosing process at the oesophago-cardiac junction...

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Unconjugated hyperbilirubinaemia in achalasia.

Moderate unconjugated hyperbilirubinaemia decreasing after pneumatic dilatation of the gastrooesophageal sphincter, so permitting a normal amount of food to be taken was observed in two patients with achalasia. Liver biopsy was performed, and hepatic digitonin-activated bilirubin UDP-glucuronyltransferase activity was decreased in both, as is usually found in patients with Gilbert's syndrome. I...

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ژورنال

عنوان ژورنال: Proceedings of the Royal Society of Medicine

سال: 1938

ISSN: 0035-9157

DOI: 10.1177/003591573803200226